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The purpose of this study is to evaluate the progression-free survival (PFS) in participants with metastatic colorectal cancer when treated with the monoclonal antibody IMC-1121B (ramucirumab) in combination with the modified FOLFOX-6 [folinic acid (FA) + fluorouracil (5-FU) + oxaliplatin, mFOLFOX-6] chemotherapy regimen as first-line therapy.

RAINBOW: A randomized, multicenter, double-blind, placebo-controlled phase 3 study of weekly paclitaxel with or without ramucirumab (IMC-1121B) drug  Synonyms: Cyramza® | IMC-1121B. Approved drug. ramucirumab is an approved drug (FDA & EMA (2014)). Compound class: Antibody. Comment:  Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular  A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase 3 Study of Weekly Paclitaxel With or Without Ramucirumab (IMC-1121B) Drug Product in  [PubMed:25281695]; Aprile G, Bonotto M, Ongaro E, Pozzo C, Giuliani F: Critical appraisal of ramucirumab (IMC-1121B) for cancer treatment: from benchside to  ABTC 0901 – An Open Label, Phase 2 Study Evaluating the Safety and Efficacy of IMC-3G3 or IMC-1121B in Patients with Recurrent Glioblastoma Multiforme.

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Furthermore, by virtue of the immunoglobulin G1 class of this antibody, it has the potential to induce antigen-dependent cellular cytotoxicity directed against endothelial cells.Completed phase I studies with IMC-1121B have demonstrated the safety and tolerability of IMC-1121B when used at clinically relevant doses, as well as marked clinical efficacy in a variety of patients with cancers refractory to available …

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2008-09-01 · ImClone began an open-label, U.S. Phase II trial to evaluate weekly Read the full 115 word article

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The anti-VEGF receptor 2 antibody IMC-1121B is a promising antiangiogenic drug being tested for treatment of breast and gastric cancer. We have determined the structure of the 1121B Fab fragment in complex with domain 3 of VEGFR2, as well as the structure of a different neutralizing anti-VEGFR2 antibody, 6.64, also in complex with VEGFR2 domain 3.
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This open-label Phase 2 single-arm study is enrolling patients with Stage IIIB or IV NSCLC. Approximately 40 patients are expected to be enrolled.

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IMC-1121B. A drug used with other drugs to treat colorectal cancer and non-small cell lung cancer that have spread to other parts of the body. It is used alone or with another drug to treat cancer of the stomach or gastroesophageal junction (area where the esophagus connects to the stomach) that is advanced or has spread to other parts of the body.

OrderHub | HP IMC Service Operation Management Software Module E-LTU från HP. Vårt förvärv av MedImmune, Inc. under 2007 har fört med sig ett antal 1121. 312.

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